Pharmaceutical compositions comprising tyrphostins

Details Pharmaceutical compositions comprising tyrphostins Pharmaceutical compositions comprising tyrphostins

C - Chemistry, Metallurgy

07

C

C07C 255/41 (2006.01) A61K 31/275 (2006.01) A61K 31/277 (2006.01) A61K 31/34 (2006.01) A61K 31/415 (2006.01) A61K 31/425 (2006.01) A61K 31/427 (2006.01) A61K 31/44 (2006.01) A61K 31/4406 (2006.01) A61K 33/24 (2006.01) C07C 255/34 (2006.01) C07C 317/44 (2006.01) C07D 213/57 (2006.01) C07D 231/38 (2006.01) C07D 277/64 (2006.01) C07D 307/64 (2006.01) C07D 405/12 (2006.01) C07D 417/12 (2006.01)

Patent

CA 2263325

Compounds useful for countering undesired toxic effects to cells, tissues or organs having formula (I) wherein: Ar is a group of formulae (i) or (ii), n is O or, when Ar has formula (i) above, then n may also be 1, R is CN, -C(S)NH2, - C(O)NHR3 or, when R1 is 4-NO2 and R2 is H or 3-OH, then R may also be a group of formulae (iii), (iv), (v), (vi) where R3 is H, phenyl, phenyl(lower alkyl) or pyridylmethyl; R1 and R2 are each independently H, OH, NO2 or, when R is CN, also CH3, F, or CF3, provided that both R1 and R2 are not simultaneously H.

L'invention concerne des composés de formule (I) destinés à contrer les effets toxiques sur des cellules, tissus ou organes. Dans ladite formule, Ar est un groupe des formules (i) ou (ii), n vaut 0 ou, lorsqu'Ar est de formule (i) n vaut 1, R représente CN, -C(S)NH¿2?, -C(O)NHR¿3?, ou lorsque R¿1? représente 4-NO¿2? et que R¿2? représente H ou 3-OH, alors R peut également être un groupe de formules (iii), (iv), (v) ou (vi), dans lesquelles R¿3? représente H, phényle, phényle(alkyle inférieur) ou pyridylméthyle; R¿1? et R¿2? représentent chacun indépendamment H, OH, NO¿2? ou, lorsque R représente CN, également CH¿3?, F ou CF¿3?, à condition que R¿1? et R¿2? ne représentent pas simultanément H.

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