A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
167/163, 167/250
A61K 9/50 (2006.01) A61K 9/127 (2006.01) A61K 47/00 (2006.01)
Patent
CA 1273575
Pharmaceutical Compositions Consisting of Acylated Phospholipids Abstract of the Disclosure Disclosed are pharmaceutical compositions consisting of a) a synthetic phospholipid of the formula Image (I), wherein m represents two or three, R1 and R2 preferably represent acyl having from 10 to 20 carbon atoms, X represents the direct bond, C1-C4-alkylene, C2-C4-alkenylene, or C1-C4-alkylene or C2-C4-alkenylene substituted by hydroxy or a pharmaceutically acceptable salt thereof, b) a synthetic phospholipid of the formula Image (II), wherein R1 and R2 repreaent the acyl group of a saturated or an unsaeurated carboxylic acid having from 10 to 20 carbon atoms and 1 - 2 double bonds, c) a compound or a mixture of compounds having pharmacological acitivity, and, optionally, d) a phospholipid from natural sources selected from the group consisting of phosphatidylcholine, phosphatidylethanolamine, phosphatidylserine, phoaphatidylinositol, phosphatidylglyceride, cardiolipin and cholesterol and its derivatives, and, optionally, a pharmaceutically acceptable carrier solution buffered to pH 7,0 - 7,8, and, optionally pharmaceutically acceptable carriers in solid form. Also disclosed are mixtures of the novel, synthetic, acylated phospholipids (I) and synthetic phosphatidylethanolamine deri- vatives, a process for the preparation of the pharmaceutical compositions, the novel, synthetic acylated phospholipids (I) themselves, a process for the preparation of the novel, synthetic, acylated phospholipids (I), and a method of use for the pharma- ceutical compositions.
516015
Nayar Rajiv
Schroit Alan J.
Fetherstonhaugh & Co.
Nayar Rajiv
Schroit Alan J.
The Board Of Regents University Of Texas System
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