A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/66 (2006.01) A61K 31/665 (2006.01)
Patent
CA 2334313
.alpha.-Tocopherylphosphocholine and salts thereof have been discovered to possess antiviral, anti-fungal, anti-inflammatory, PAF-antagonist, and ultra- violet radiation-blocking activities. The compounds are effective to treat a variety of ailments, including diseases of the airways and pulmonary passages. The compound and salts have also been discovered to be capable of forming liposomes. The present invention thus provides methods of treating viral and fungal infections, respiratory disorders, inflammatory disorders and pathophysiological conditions due to PAF activity in a mammal by administering to the mammal .alpha.-tocopherylphosphocholine or a pharmaceutically acceptable salt thereof. The invention also provides pharmaceutical compositions comprising .alpha.-tocopherylphosphocholine or a pharmaceutically acceptable salt thereof and a pharmaceutically acceptable carrier. Further, the invention provides liposomes which comprise .alpha.- tocopherylphosphocholine or a salt thereof as a structural component of the liposome bilayer.
On a découvert que l'.alpha.-tocophérylphosphocholine et ses sels possédaient des pouvoirs antiviraux, antifongiques, anti-inflammatoires, antagonistes du PAF, et bloquants du rayonnement ultraviolet. Ces composés sont efficaces pour traiter une grande variété d'affections, notamment des maladies des voies aériennes et des voies pulmonaires. Ce composé et ses sels se sont également avérés pouvoir former des liposomes. L'invention décrit ainsi des méthodes pour traiter des infections virales et fongiques, des troubles respiratoires, des troubles inflammatoires et des états pathophysiologiques causés par l'activité de PAF chez un mammifère en lui administrant de l'.alpha.-tocophérylphosphocholine ou un sel pharmaceutiquement acceptable de celle-ci. L'invention concerne également des compositions pharmaceutiques comprenant de l'.alpha.-tocophérylphosphocholine ou un sel pharmaceutiquement acceptable de celle-ci et un excipient pharmaceutiquement acceptable. D'autre part, l'invention concerne des liposomes renfermant de l'.alpha.-tocophérylphosphocholine ou un sel de celle-ci comme constituant structural de la bicouche liposomique.
Peterson Andrew C.
Pruss Thaddeus P.
Yazdi Parvin I.
Borden Ladner Gervais Llp
Clarion Pharmaceuticals Inc.
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