Pharmaceutical compositions containing a solid dispersion of...

Details Pharmaceutical compositions containing a solid dispersion of... Pharmaceutical compositions containing a solid dispersion of...

A - Human Necessities

61

K

A61K 47/38 (2006.01) A61K 9/10 (2006.01) A61K 47/30 (2006.01)

Patent

CA 2448864

A pharmaceutical composition comprises a dispersion comprising a low- solubility drug and a matrix combined with a concentration-enhancing polymer. At least a major portion of the drug is amorphous in the dispersion. The compositions improve the stability of the drug in the dispersion, and/or the concentration of drug in a use environment.

L'invention concerne des compositions pharmaceutiques contenant une dispersion solide composée d'un médicament peu soluble et d'une matrice combinée à un polymère améliorant la concentration. Au moins une partie majeure dudit médicament est amorphe dans la dispersion. Les compositions selon l'invention permettent d'améliorer la stabilité du médicament dans la dispersion et/ou la concentration du médicament dans un environnement d'utilisation.

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