A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 47/48 (2006.01)
Patent
CA 2293700
Prodrugs which can be activated by enzymes, are formulated for sequential administration, with enzyme conjugates. Either or each component comprises a polymeric carrier which allows it to be directed preferentially to the target tissue. A new polymer-prodrug conjugate is cleavable by Cathepsin B or other thiol-dependent protease. The invention is of particular utility for targeting solid tumours.
On formule des promédicaments qui peuvent être activés par des enzymes, ces promédicaments étant destinés à être administrés séquentiellement avec les conjugués d'enzymes. Tous les constituants ou chaque constituant comprennent/comprend un vecteur polymère qui permet de le/les diriger préférentiellement sur le tissu cible. Un nouveau conjugué polymère-promédicament est séparable par la Cathepsine N ou une autre protéase thiol-dépendante. Cette invention est particulièrement utile pour cibler des tumeurs solides.
Duncan Ruth
Satchi-Fainaro Ronit
Cassan Maclean
The School Of Pharmacy University Of London
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