Pharmaceutical compositions containing buffered ortho ester...

Details Pharmaceutical compositions containing buffered ortho ester... Pharmaceutical compositions containing buffered ortho ester...

A - Human Necessities

61

K

A61K 47/34 (2006.01)

Patent

CA 2243988

The present invention relates to a pharmaceutical composition for the controlled release of therapeutic agents from carboxylic acid ortho ester polymers. The composition contains a pharmaceutically acceptable salt of an acid, which together with the acid R1-COOH being liberated from the decomposition of the ortho ester polymer (I) forms a buffer system in a physiologically acceptable pH-range.

La présente invention se raporte à une composition pharmaceutique conçue pour la libération contrôlée d'agents thérapeutiques à partir d'ortho ester polymères d'acide carboxylique. Cette composition renferme un sel pharmaceutiquement acceptable d'un acide qui, avec R1-COOH acide libéré par la décomposition de l'ortho ester polymère (I), forme un système tampon dans une plage de pH physiologiquement acceptable.

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