A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/40 (2006.01) A61K 9/107 (2006.01) A61K 9/48 (2006.01) A61K 31/404 (2006.01) A61K 47/00 (2006.01)
Patent
CA 2273990
The invention concerns an anhydrous solubilising/stabilising system, emulsifiable or microemulsifiable in water, for the solubilisation of hydrophobic N-sulphonyl indolin derivatives of formula (I) characterised in that it contains one or several constituents selected among amphiphilic compounds, non-ionic hydrophilic surfactants and non-ionic hydrophilic compounds having both amphiphilic and surface-active properties, being understood that said system contains either at least a mixture of an amphiphilic compound and a non-ionic hydrophilic surfactant, or a non-ionic hydrophilic compound having both surface-active and amphiphilic properties.
La présente invention concerne un système solubilisant/stabilisant anhydre, émulsionnable ou microémulsionnable dans l'eau, pour la solubilisation des dérivés hydrophobes de N-sulfonyl indoline de formule (I) caractérisé en ce qu'il comprend un ou plusieurs constituants choisis parmi des composés amphiphiles, des agents tensioactifs hydrophiles non ioniques et des composés hydrophiles non ioniques doués à la fois de propriétés amphiphiles et tensioactives, étant entendu que ledit système comprend soit au moins un mélange d'un composé amphiphile et d'un agent tensioactif hydrophile non ionique, soit au moins un composé hydrophile non ionique doué à la fois de propriétés tensioactives et amphiphiles.
Fuller Simon John
Gautier Jean-Claude
Robic
Sanofi
Sanofi-Synthelabo
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