C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
167/208, 167/251
C07C 237/04 (2006.01) A61K 31/21 (2006.01) A61K 31/23 (2006.01) C07C 235/10 (2006.01) C07C 235/26 (2006.01) C07C 235/40 (2006.01) C07C 237/08 (2006.01) C07C 275/10 (2006.01) C07C 275/14 (2006.01) C07C 275/16 (2006.01) C07C 275/26 (2006.01) C07D 295/13 (2006.01) C07D 295/15 (2006.01) C07D 295/215 (2006.01)
Patent
CA 2001255
ABSTRACT Nitroxyalkylamine derivative of the general formula: Image (I) wherein R1 is a hydrogen atom, a straight-chained or branched, saturated or unsaturated C1-C8-alkyl radical, a C3-C8-cycloalkyl or C3-C8-cycloalkenyl radical, an aminocarbonyl, C1-C6-alkylaminocarbonyl or di-C1-C6- alkylaminocarbonyl radical, R2 is a hydrogen atom, a straight-chained or branched, saturated or unsaturated C1-C6-alkyl radical or a C3-C8-cycloalkyl or cyclo- alkenyl radical or R2, together with R1 and the nitrogen atom to which they are attached, form a heteroaliphatic ring containing up to 6 carbon atoms in which one or two carbon atoms can be replaced by nitrogen or oxygen atoms, A is a valency bond or a straight-chained or branched alkylene radical containing up to 8 carbon atoms, in which a -CH2- group can be replaced by a cycloalkylene radical containing 3 to 7 carbon atoms, B is a straight-chained or branched alkylene radical containing up to 8 carbon atoms, in which a -CH2- group can be replaced by a cycloalkylene radical containing 3 to 7 carbon atoms and X is an -NR3-CO- or -CO-NR3- radical, in which R3 is a hydrogen atom or a saturated or unsaturated alkyl radical containing up to 6 carbon atoms or, when X is an -NR3-CO- radical, R3, together with the nitrogen atom and a carbon atom of the group A, bridge a heterocyclic ring containing 4 to 6 carbon atoms or R3, together with R2, A and the two nitrogen atoms, bridge a heterocyclic ring containing 3 to 5 carbon atoms; and the optically- active forms and physiologically compatible, pharma- ceutically acceptable salts thereof, may be used in the prophylaxis or treatment of heart and circulatory diseases, for example, angina pectoris.
Bartsch Wolfgang
Michel Helmut
Schultz Michael
Simon Herbert
Boehringer Mannheim Gmbh
Swabey Ogilvy Renault
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