Pharmaceutical compositions containing nonionic surfactants

Details Pharmaceutical compositions containing nonionic surfactants Pharmaceutical compositions containing nonionic surfactants

A - Human Necessities

61

K

A61K 47/34 (2006.01) A61K 9/48 (2006.01) A61K 38/00 (2006.01) A61K 47/08 (2006.01) A61K 47/10 (2006.01) A61K 47/14 (2006.01) A61K 47/26 (2006.01)

Patent

CA 2145763

Pharmaceutical compositions comprise an enzymatically labile pharmaceutically active agent which is permeable through the intestinal wall or requires an intestinal permeability enhancer to permeate the intestinal wall, and at least one nonionic sur- factant which is capable of protecting said active agent against deactivation by enzymes. A method for the inhibition of the de- gradation of an enzymatically labile pharmaceutically active agent by gastrointestinal enzymes comprises combining said agent with a nonionic surfactant.

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