Pharmaceutical compositions containing plasma protein

Details Pharmaceutical compositions containing plasma protein Pharmaceutical compositions containing plasma protein

A - Human Necessities

61

K

A61K 47/42 (2006.01) A61K 9/08 (2006.01)

Patent

CA 2269923

The invention is related to water-soluble products and pharmaceutical formulations in solid or liquid form mainly for parenteral use. They consist of or comprise a therapeutically active substance (having low aqueous solubility and a substantial binding affinity to plasma proteins) and a plasma protein fraction in controlled aggregation state, whereby the said active substance and the said protein fraction are bound to each other by way of noncovalent bonds. It also covers processes for the preparation of the product and pharmaceutical formulation.

L'invention concerne des produits hydrosolubles et des formulations pharmaceutiques sous forme solide ou liquide destinés essentiellement à une utilisation parentérale. Ils se composent d'une substance thérapeutique active (présentant une faible solubilité aqueuse et une affinité de liaison substantielle vis-à-vis de protéines du plasma) et d'une fraction de protéine du plasma dans un état d'agrégation régulé, de manière que ladite substance active et ladite fraction de protéine sont liées l'une à l'autre à l'aide de liaisons non covalentes. L'invention concerne également les procédés de préparation du produit et de la formulation pharmaceutique.

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