A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/202 (2006.01) A61K 9/48 (2006.01) A61K 45/06 (2006.01)
Patent
CA 2570184
Polyunsaturated fatty acid (~PUFA~) or a pharmacologically acceptable salt or derivative thereof (such as EPA and/or DHA) is used in combination with at least one of an immunosuppressive agent or an antineoplastic agent or a pharmacologically acceptable salt or derivative thereof in the treatment of conditions involving acutely or chronically inadequate immune response by topical application of said active agents to at least a portion of the intestinal mucosa. Specific conditions that may be treated include chronic inflammatory disease (e.g. Chrohn~s disease and ulcerative colitis) and tumour disease (e.g. bowel cancer and prostate cancer). One advantage of preferred embodiments of the invention is that bioavailability of immunosuppressive or antineoplastic agents is increased.
On utiliser un acide gras poly-insaturé ( PUFA ) ou bien un sel ou un dérivé phamacologiquement acceptable de cet acide (tel que EPA et/ou DHA) en combinaison avec au moins un agent immunosuppresseur ou un agent anti-néoplasique, ou bien un sel ou un dérivé pharmacologiquement acceptable de des agents, pour le traitement de troubles impliquant une réponse immunitaire inadéquate de manière aiguë ou chronique par application topique desdits agents actifs sur au moins une partie de la muqueuse intestinale. Les troubles spécifiques pouvant être traités comprennent les maladies inflammatoires (telles que la maladie de Crohn et la colite ulcéreuse) et les maladies tumorales (telles que le cancer des intestins et le cancer de la prostate). Dans des modes de réalisation préférés, l'invention offre notamment l'avantage d'accroître la biodisponibilité des agents immunosuppresseurs ou anti-néoplasiques.
Mittmann Ulrich
Sachetto Jean-Pierre
Mittmann Ulrich
Sachetto Jean-Pierre
Sim & Mcburney
Tillotts Pharma Ag
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