Pharmaceutical compositions containing protein nma0939

Details Pharmaceutical compositions containing protein nma0939 Pharmaceutical compositions containing protein nma0939

A - Human Necessities

61

K

A61K 39/095 (2006.01) A61P 31/04 (2006.01) C12Q 1/68 (2006.01)

Patent

CA 2633424

The present invention is related to field of medicine, particularly to the development of pharmaceutical formulations containing NMA0939 protein. Formulations described in this invention are able to confer protection against different diseases caused or not by pathogenic agents. NMA0939 protein was identified as a Neisseria meningitidis outer membrane vesicle component, and it was obtained through recombinant DNA technology being its immunogenicity and protective activity evaluated in animal models. Due to the high level of conservation the NMA0939 coding gene has shown, pharmaceutical compositions containing this protein have a high value as inducers of a cross-reactive immune response. Formulations presented in this invention are applicable to the field of human medicine.

La présente invention concerne le domaine de la médecine, en particulier la mise au point de compositions pharmaceutiques contenant la protéine NMA0939. Les compositions de la présente invention ont un rôle de protection contre différentes maladies causées ou non par des agents pathogènes. La protéine NMA0939 a été identifiée comme composant des préparations de vésicules à membrane externe Neisseria meningitidis, et obtenue par la technologie de l'ADN de recombinaison, et son immunogénicité et son activité protectrice ont été évaluées dans des modèles animaux. Grâce au niveau élevé de conservation du gène codant pour la protéine NMA0939, les compositions la contenant possèdent une valeur élevée comme antigène inducteur d'une réponse immune à large réactivité. Les compositions de l'invention sont applicables en médecine humaine.

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