C - Chemistry – Metallurgy – 12 – P
Patent
C - Chemistry, Metallurgy
12
P
195/122, 167/202
C12P 19/30 (2006.01) A61K 31/70 (2006.01) C07H 13/04 (2006.01) C07H 19/10 (2006.01)
Patent
CA 1219539
Pharmaceutical compositions containing the cytidine monophosphate of 5-acetamido-3,5-dideoxy-D-glycero-D-galactononulosaminic acid and a method for preparing said compound ABSTRACT OF THE DISCLOSURE The invention relates to pharmaceutical compositions for use in the therapy of pathological states related to disturbances of the nervous stimulus in the central (CNS) and peripheral (PNS) nervous system containing as an active substance the cytidine monophosphate of 5-acetamido-3,5-dideoxy-D-glycero-D-galactono- nulosaminic acid. Moreover the invention relates to an improved method for preparing said compound by the condensation of cytidine triphosphate (CTP) with N-acetylneuraminic acid (NANA), catalyzed by the enzyme CMP-transferase (CMP-acylneuraminate synthase) (EC 2.7.7.43).
448517
Decorte Enio
Miccoli Pietro
Crc - Compagnia Di Ricerca Chimica S.p.a.
Smart & Biggar
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