Pharmaceutical compositions containing water-soluble...

A - Human Necessities – 61 – K

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A61K 31/66 (2006.01) A61K 45/06 (2006.01)

Patent

CA 2480881

The present invention is directed to pharmaceutical compositions containing water-soluble prodrugs of propofol and methods of administering the prodrug. In one aspect, a method of inducing and/or maintaining a generalized anesthetic state comprises administering by parenteral infusion a prodrug of propofol in an amount sufficient to cause and/or maintain loss of consciousness. In another aspect, a prodrug of propofol is administered for producing a sedated state in a subject.

L'invention concerne des compositions pharmaceutiques contenant des promédicaments hydrosolubles à base de propofol et des procédés d'administration associés. Un aspect de cette invention concerne un procédé permettant de provoquer et/ou de maintenir un état anesthésique généralisé; ce procédé consiste à administrer par perfusion parentérale un promédicament à base de propofol en quantité suffisante pour provoquer et/ou maintenir une perte de conscience. Dans un autre aspect de cette invention, un promédicament à base de propofol est administré de manière à plonger le sujet dans un état tranquille.

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