Pharmaceutical compositions derived from...

A - Human Necessities – 61 – K

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Details

A61K 9/107 (2006.01) A61K 9/06 (2006.01) A61K 31/07 (2006.01) A61K 31/355 (2006.01) A61K 31/56 (2006.01) A61K 38/13 (2006.01) A61K 47/36 (2006.01) A61K 47/42 (2006.01)

Patent

CA 2190869

The invention relates to a pharmaceutical composition comprising a microemulsion made up of a hydrophilic component, a lipophilic component, a surfactant and a drug, wherein the hydrophilic component, the lipophilic component and the surfactant form, when examined on a macroscopic scale, a one-phase solution. The hydrophilic component is dispersed as colloidal droplets in the lipophilic component, or the lipophilic component is dispersed as colloidal droplets in the hydrophilic component. According to still another alternative the hydrophilic and the lipophilic components form a microemulsion with bicontinuous structure wherein said components form elongated adjacent channels. The drug is dissolved in the dispersed component or, in case of a microemulsion with a bicontinuous structure, in the hydrophilic or the lipophilic component. The microemulsion is stabilized by means of the surfactant. It is characteristic that a gelatinizer and water are added to the microemulsion thereby bringing the microemulsion into a gel form.

L'invention concerne une composition pharmaceutique comprenant une microémulsion constituée d'un composant hydrophile, d'un composant lipophile, d'un tensioactif et d'un médicament, micro-émulsion dans laquelle le composant hydrophile, le composant lipophile et le tensioactif forment, lorsqu'on les examine à l'échelle macroscopique, une solution à une phase. Le composant hydrophile est dispersé sous forme de gouttelettes colloïdales dont le composant lipophile, ou bien c'est le composant lipophile qui est dispersé sous forme de gouttelettes colloïdales dans le composant hydrophile. Selon une autre variante, le composant hydrophile et le composant lipophile forment une microémulsion pourvue d'une structure bicontinue dans laquelle lesdits composants forment des canaux adjacents allongés. Le médicament est dissous dans le composant dispersé, ou bien, dans le cas d'une microémulsion à structure bicontinue, dans le composant hydrophile ou dans le composant lipophile. La microémulsion est stabilisée au moyen du tensioactif. L'invention se caractérise en ce qu'un gélifiant et de l'eau sont ajoutés à la microémulsion, ce qui entraîne la transformation de celle-ci en un gel.

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