Pharmaceutical compositions exhibiting thrombopoietin...

C - Chemistry – Metallurgy – 07 – D

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C07D 277/34 (2006.01) A61K 31/425 (2006.01) A61K 31/426 (2006.01) A61K 31/427 (2006.01) A61K 31/429 (2006.01) A61K 31/4439 (2006.01) A61K 31/4709 (2006.01) A61K 31/4725 (2006.01) A61P 7/04 (2006.01) A61P 43/00 (2006.01) C07D 275/02 (2006.01) C07D 277/20 (2006.01) C07D 277/36 (2006.01) C07D 277/46 (2006.01) C07D 277/54 (2006.01) C07D 277/60 (2006.01) C07D 277/82 (2006.01) C07D 417/12 (2006.01) C07D 417/14 (2006.01) C07D 513/04 (2006.01)

Patent

CA 2380206

Drug compositions containing as the active ingredient compounds of general formula (I), prodrugs of the same, pharmaceutically acceptable salts of both, or solvates of them and exhibiting thrombopoietin receptor agonism: wherein X1 is optionally substituted heteroaryl or the like; Y1 is NRACO-(CH2)0-2- or the like (wherein RA is hydrogen or the like); Z1 is optionally substituted allylene or the like; and A1 is a ring represented by general formula (II) or (III):

L'invention concerne des compositions médicamenteuses contenant comme ingrédients actifs des composés représentés par la formule générale (I), ainsi que des promédicaments de ces compositions médicamenteuses, des sels de ces compositions médicamenteuses et de leurs promédicaments acceptables du point de vue pharmaceutique, ou leurs solvates, ces compositions possédant une activité agoniste du récepteur de la thrombopoïétine. Dans la formule (I) selon l'invention, X?1¿ représente éventuellement un hétéroaryle substitué ou analogue, Y?1¿ représente NR?A¿CO-(CH¿2?)¿0-2?- ou analogue (R?A¿ désignant un hydrogène ou analogue) ; Z?1¿ représente éventuellement un allylène substitué ou analogue ; et A?1¿ désigne un cycle représenté par la formule générale (II) ou (III).

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