Pharmaceutical compositions for angiogenic therapy

A - Human Necessities – 61 – K

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A61K 48/00 (2006.01) A61P 9/10 (2006.01) C12N 15/12 (2006.01) C12N 15/61 (2006.01)

Patent

CA 2413768

Medicinal compositions for angiogenic therapy which contain as the active ingredients at least one member selected from among substances having a vasodilating effect and/or a platelet aggregation inhibitory effect and substances producing the same, and a gene encoding an angiogenesis factor; agents for potentiating the angiogenic effect of a gene encoding an angiogenesis factor which contain as the active ingredient at least one member selected from among substances having a vasodilating effect and/or a platelet aggregation inhibitory effect and substances producing the same; an angiogenic agent which contains prostacyclin synthase gene as the active ingredient; medicinal compositions for angiogenic therapy which contain ets-1 gene and another gene encoding an angiogenesis factor as the active ingredients; an agent for potentiating the angiogenic effect of a gene encoding an angiogenesis factor which contain ets-1 gene as the active ingredient; and an angiogenic agent which contains ets-1 gene as the active ingredient.

L'invention concerne des compositions médicales destinées à une thérapie angiogénique et contenant comme principes actifs au moins un élément sélectionné parmi les substances ayant un effet vasodilatateur et/ou un effet inhibiteur sur l'agrégation plaquettaire et les substances les produisant; et un gène codant pour un facteur angiogénique ; des agents permettant de potentialiser l'effet angiogénique d'un gène codant pour un facteur angiogénitique qui contient comme principe actif au moins un élément sélectionné parmi les substances ayant un effet vasodilatateur et/ou un effet inhibiteur sur l'agrégation plaquettaire et les substances les produisant ; un agent angiogénique contenant le gène de synthase de prostacycline comme principe actif ; des compositions médicales de thérapie angiogénique contenant le gène ets-1 et un autre gène codant pour un facteur angiogénique comme principes actifs ; un agent de potentialisation de l'effet angiogénique d'un gène codant pour un facteur angiogénique contenant le gène ets-1 comme principe actif ; et un agent angiogénique contenant le gène ets-1 comme principe actif.

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