Pharmaceutical compositions for headache, migraine, nausea...

A - Human Necessities – 61 – K

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A61K 31/66 (2006.01) A61K 31/155 (2006.01) A61K 31/17 (2006.01)

Patent

CA 2420410

The use of S-alkylisothiouronium derivatives, such as, but not limited to the preferred compound S-ethylisothiouronium diethylsphosphate, for the treatment of headache, in particular migraine, as well as for the prevention or treatment of nausea and vomiting, is disclosed. The compositions of the invention are effective in preventing or alleviating emesis associated with migraine or other medical conditions such as chemotherapy or radiotherapy, as well as other symptoms of migraine including phonophobia and photophobia.

L'invention concerne l'utilisation de dérivés de S-alkylisothiouronium, telle que la composition préférée de diéthylphosphate de S-éthylisothiouronium, par exemple, destinés au traitement des céphalées, en particulier de la migraine, ainsi qu'à la prévention et au traitement des nausées et des vomissements. Ces compositions sont efficaces dans la prévention ou le soulagement de vomissements associés à la migraine ou à d'autres états pathologiques, tels que ceux induits par la chimiothérapie ou la radiothérapie, ainsi que d'autres symptômes de la migraine, y compris la phonophobie et la photophobie.

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