A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 47/18 (2006.01) A61K 38/05 (2006.01) A61K 38/06 (2006.01) A61K 38/55 (2006.01) A61K 9/107 (2006.01) A61K 9/14 (2006.01)
Patent
CA 2472249
Disclosed are pharmaceutical compositions of hepatitis C viral protease inhibitors having improved bioavailability, and methods of using these compositions for inhibiting the replication of the hepatitis C virus (HCV) and for the treatment of an HCV infection. These compositions include co-solvent systems, lipid based systems, solid dispersions and granulations, and all comprise the hepatitis C viral protease inhibitor, at least one pharmaceutically acceptable amine and optionally one or more additional ingredients.
L'invention concerne des compositions pharmaceutiques d'inhibiteurs de protéase virale de l'hépatite C présentant une biodisponibilité améliorée, et des méthodes d'utilisation de ces compositions permettant d'inhiber la réplication du virus de l'hépatite C (HCV) et de traiter une infection HCV. Ces compositions comprennent des systèmes de co-solvant, des sites à base de lipide, des dispersions et des granulations solides, comprenant tous l'inhibiteur de protéase virale de l'hépatite C, au moins une amine pharmaceutiquement acceptable, et éventuellement, un ou plusieurs ingrédients complémentaires.
Chen Shirlynn
Mei Xiaohui
Boehringer Ingelheim Pharmaceuticals Inc.
Fetherstonhaugh & Co.
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