Pharmaceutical compositions for immunosuppression,...

C - Chemistry – Metallurgy – 07 – D

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C07D 493/06 (2006.01) A61K 31/335 (2006.01) A61K 31/336 (2006.01) A61K 38/21 (2006.01) A61P 37/06 (2006.01) C07D 303/06 (2006.01) C07D 493/08 (2006.01)

Patent

CA 2286903

Compounds and uses thereof for the preparation of pharmaceutical compositions as immunosuppressants, anticancer agents, and antiviral agents, the compound having formula (IV) where R is H, PO3~, alkyl of 1 to 12 carbon atoms substituted or unsubstituted, straight chain or branched, 0 to 6 double bonds, (CH2)n morpholine where n=1-4, morpholinomethylphenyl, orthoaminophenyl, orthohydroxyphenyl, (CH2)n COOR2 where n=1-4; where R2 is H, an alkalai metal salt, an alkaline earth metal salt, NH4+, N+(R3)4, where R3 is independently selected from the group consisting of H and alkyl of 1 to 4 carbon atoms, COR1 wherein R1 is selected from the group consisting of H, (CH2)n CH3, where n=0-6, (CH2)n COOR1 where n=1-4 and R2 is previously defined, (CH2)n N+(R3)3 wherein n=1-4, and (CH2)n SO3- where N=1-4.

L'invention concerne des composés et leurs utilisations pour la préparation de compositions pharmaceutiques comme agents immunosuppresseurs, anticancéreux et antiviraux, lesdits composés présentant la formule (IV), dans laquelle R représente H, PO3<=>, alkyle (C1-C12), substitué ou non, linéaire ou ramifié, 0 à 6 liaisons doubles, (CH2)n morpholine, n étant compris entre 1 et 4, morpholinométhylphényle, orthoaminophényle, orthohydroxyphényle, (CH2)nCOOR2, n étant compris entre 1 et 4; R2 représente H, un sel de métal alcalin, un sel de métal alcalinoterreux, NH4<+>, N<+>(R3)4, R3 étant sélectionné indépendamment dans le groupe comprenant H, et alkyle (C1-C4); COR1, R1 étant sélectionné dans le groupe comprenant H, (CH2)nCH3, n étant compris entre 0 et 6, (CH2)nCOOR2, n étant compris entre 1 et 4, et R2 ayant la définition mentionnée précédemment, (CH2)nN<+>(R3)4, n étant compris entre 1 et 4, et (CH2)nSO3<->, n étant compris entre 1 et 4.

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