Pharmaceutical compositions for intranasal administration of...

A - Human Necessities – 61 – K

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A61K 31/662 (2006.01) A61P 25/08 (2006.01)

Patent

CA 2521394

Pharmaceutical compositions for intranasal administration are provided that contain at least one compound of formula (I) or a pharmaceutically acceptable salt thereof: and one or more pharmaceutically acceptable additives for forming a composition for intranasal administration. Also provided are methods of treating one or more conditions in a mammal associated with a glutamate abnormality that includes administering intranasally to a mammal a therapeutically effective amount of a compound of formula (I) or a pharmaceutically acceptable salt thereof.

L'invention concerne des compositions pharmaceutiques pour administration intranasale qui contiennent au moins un composé de la formule (I) ou un sel de celui-ci pharmaceutiquement acceptable, et au moins un additif pharmaceutiquement acceptable pour former une composition destinée à une administration intranasale. L'invention concerne également des procédés de traitement d'au moins un état chez un mammifère associé à une anomalie du glutamate, qui consistent à administrer par voie nasale à un mammifère une dose thérapeutiquement efficace d'un composé de la formule (I) ou d'un sel de ce dernier pharmaceutiquement acceptable.

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