Pharmaceutical compositions for nasal delivery

A - Human Necessities – 61 – K

Patent

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Details

A61K 31/48 (2006.01) A61K 9/00 (2006.01) A61K 9/19 (2006.01) A61K 31/485 (2006.01)

Patent

CA 2516459

According to the invention there is provided a powdered pharmaceutical formulation suitable for nasal delivery which is a freeze-dried blend of active material and excipient(s) containing: 0.5 - 50 % by wt of active material 50 - 99.5 % by wt of excipient(s), and in which at least 0.1 % by wt of the blend is an amorphous state, which can be directly obtained by freeze drying without the need for milling and without containing the pronounced low particles defined as finings. Such powders retain free-flowing properties on storage, are physically and chemically stable and are readily soluble.

La présente invention a trait à une préparation pharmaceutique en poudre apte à une administration nasale consistant en un mélange lyophilisé de principe actif et d'excipients contenant : 0,5 à 50 % en poids de principe actif, 50 à 95,5 % en poids d'excipients, et dans lequel au moins 0,1 % en poids du mélange est dans un état amorphe, qui peut être obtenue directement par lyophilisation sans nécessiter un broyage et ne contenant pas une quantité importante de particules désignées particules collantes. De tels poudres maintiennent leur propriétés de fluidité lors du stockage, et présentent une stabilité physique et chimique et sont facilement solubles.

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