Pharmaceutical compositions for oral use

Details Pharmaceutical compositions for oral use Pharmaceutical compositions for oral use

A - Human Necessities

61

K

A61K 45/08 (2006.01) A61K 9/08 (2006.01) A61K 9/10 (2006.01) A61K 31/00 (2006.01) A61K 31/18 (2006.01) A61K 31/335 (2006.01) A61K 31/351 (2006.01) A61K 31/445 (2006.01) A61K 31/55 (2006.01) A61K 47/10 (2006.01) A61K 47/12 (2006.01) A61K 47/24 (2006.01) A61K 47/44 (2006.01) A61P 31/18 (2006.01) A61P 43/00 (2006.01) C07D 295/135 (2006.01) C07D 309/14 (2006.01) C07D 313/08 (2006.01) C07D 405/12 (2006.01) C07D 407/12 (2006.01) C07D 409/12 (2006.01)

Patent

CA 2393530

Medicinal compositions for oral use to be used as preparations for oral administration showing little scatter in the concentration of a compound, which is hardly soluble in water and shows a CCR5 antagonism, or its salt in blood, having a very high oral absorbability and being useful in preventing and treating various HIV infections in humans, characterized in that the above- described compound or its salt is dissolved or dispersed in a carrier containing at least one constituent selected from among amphipathic substances, alcohols and lipids.

La présente invention concerne des compositions médicinales à usage par voie orale s'utilisant comme les préparations à administration orale présentant peu de variation dans la concentration d'un composé, qui se dissout difficilement dans l'eau et qui présente un antagonisme de CCR5, ou son sel dans le sang, présentant une très forte absorbabilité orale et étant utilisées pour empêcher et traiter diverses infections par VIH chez les humains, caractérisées en ce que le composé précité ou son sel est dissous ou dispersé dans un excipient contenant au moins un constituent sélectionné parmi des substances anphipathiques, des alcools et des lipides.

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