C - Chemistry – Metallurgy – 07 – H
Patent
C - Chemistry, Metallurgy
07
H
C07H 21/00 (2006.01) A61K 31/00 (2006.01) A61K 31/7088 (2006.01) A61K 31/7125 (2006.01) A61K 33/06 (2006.01) A61K 33/24 (2006.01) A61K 33/42 (2006.01) A61K 38/17 (2006.01) A61K 38/19 (2006.01) A61K 38/20 (2006.01) A61K 38/45 (2006.01) A61K 39/39 (2006.01) A61K 48/00 (2006.01) A61P 31/00 (2006.01) A61P 35/00 (2006.01) A61P 37/00 (2006.01) C12N 5/00 (2006.01) C12N 5/06 (2006.01) C12N 5/08 (2006.01) C12N 15/11 (2006.01) C12Q 1/02 (2006.01) C12Q 1/48 (2006.01) C12Q 1/68 (2006.01) G01N 33/50 (2006.01)
Patent
CA 2447360
Pharmaceutical composition for preventing or treating a Th1 cell- or Th2-cell- related disease in a human or an animal by modulating the Th1/Th2 ratio comprising an active substance consisting of (i) IL-4 and SDF-1.alpha., or IL- 2 and SDF-1.alpha., respectively, as well as modulators thereof, (ii) an IL-4 stimulating adjuvant and SDF-1.alpha., or an IL-2 stimulating adjuvant and SDF- 1.alpha., respectively, (iii) a modulator of the tyrosine kinases Syk or ZAP- 70, or (iv) a modulator of the nuclear factors of activated T cells NFAT1 or NFAT2.
L'invention concerne une composition pharmaceutique destinée à prévenir ou traiter une maladie associée aux cellules Th1 et Th2 chez un humain ou un animal par modulation du rapport Th1/Th2. Cette composition comprend une substance active constituée par (i) IL-4 et SDF-1.alpha. ou IL-2 et SDF-1.alpha. ainsi que leurs modulateurs, (ii) un adjuvant stimulateur d'IL-4 et SDF-1.alpha. ou un adjuvant stimulateur d'IL-2 et SDF-1.alpha., (iii) un modulateur des tyrosine kinases Syk ou ZAP-70, ou (iv) un modulateur des facteurs nucléaires des cellules T activées NFAT1 ou NFAT2.
Jinquan Tan
Poulsen Lars Kaergaard
Alk-Abello A/s
Ridout & Maybee Llp
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