A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/29 (2006.01) A61K 9/00 (2006.01) A61K 9/12 (2006.01) A61K 9/72 (2006.01) A61K 47/28 (2006.01) A61K 47/40 (2006.01) C07K 14/635 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2230929
A pharmaceutical composition for the nasal delivery of compounds useful for treating osteoporosis, comprising an effective amount of a physiologically active truncated analog of PTH or PTHrp, or salt thereof, in which amino acid residues (22-31) form an amphipathic .alpha.-helix, said residues (22-31) selected from (SEQ ID NOS: 85, 86, 26, 27, 28, 29, and 30); an absorption enhancer selected from the group consisting of dimethyl-.beta.-cyclodextrin and the bile acid surfactants; and water is provided.
Composition pharmaceutique servant à effectuer l'administration nasale de composés utiles pour traiter l'ostéoporose, et comprenant une quantité efficace d'un analogue tronqué physiologiquement actif de PTH ou PTHrp, ou d'un de ses sels, dans lequel les restes d'acides aminés (22-31) constituent une .alpha.-hélice amphipathique, lesdits reste (22-31) étant sélectionnés dans (SEQ ID NOS: 85, 86, 26, 27, 28, 29 et 30); un amplificateur d'absorption sélectionné dans le groupe constitué par diméthyle-.beta.-cyclodextrine et par des tensioactifs d'acides biliaires; et de l'eau.
Krstenansky John Leonard
Nestor John Joseph Jr.
Piazza Christin Teresa
Radomsky Michael Lloyd
Vickery Brian Henry
Dennison Associates
Syntex (u.s.a.) Llc
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