Pharmaceutical compositions for the oral or rectal...

Details Pharmaceutical compositions for the oral or rectal... Pharmaceutical compositions for the oral or rectal...

A - Human Necessities

61

K

A61K 9/28 (2006.01) A61K 9/00 (2006.01) A61K 9/20 (2006.01)

Patent

CA 2663548

Pharmaceutical compositions with differentiated, controlled and/or site-specific release are claimed for the oral or rectal administration of peptide or protein substances, including antibodies and soluble receptors capable of antagonising the pathogenetic role of several cell mediators such as interleukines, chemokines, growth factors, tissue necrosis factors, and interferons. Through the incorporation of the peptide or protein substance inside a controlled and/or site-specific release preparation, the application of this invention permits transporting the substances directly into the intestinal environment where a reduced quantity of proteolytic enzymes is present, a less aggressive microenvironment for the integrity of the protein structure and sequence.

Compositions pharmaceutiques à libération différentiée, contrôlée et/ou spécifique du site pour administration par voie orale ou rectale de substances peptidiques ou protéiques, dont des anticorps et des récepteurs solubles capables de contrer le rôle pathogène de plusieurs médiateurs cellulaires tels que les interleukines, chimiokines, facteurs de croissance, facteurs de nécrose cellulaire et interférons. En intégrant des substances peptidiques ou protéiques dans une préparation à libération contrôlée et/ou spécifique du site, il est possible de transporter directement ces substances dans l'environnement intestinal où une quantité réduite d'enzymes protéolytiques est présente, ce qui équivaut à un micro-environnement moins agressif pour l'intégrité de la structure et de la séquence protéique.

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