Pharmaceutical compositions for the prevention and treatment...

A - Human Necessities – 61 – K

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Details

A61K 31/435 (2006.01) A61K 31/352 (2006.01) A61K 31/4353 (2006.01) A61P 9/00 (2006.01) A61P 29/00 (2006.01) C07D 471/02 (2006.01) C07D 491/04 (2006.01)

Patent

CA 2617213

The present invention relates to polyphenol-like compounds that are useful for inhibiting VCAM-1 expression, MCP-1 expression and/or SMC proliferation in a mammal. The disclosed compounds are useful for regulating markers of inflammatory conditions, including vascular inflammation, and for treatment and prevention of inflammatory and cardiovascular diseases and related disease states.

L'invention concerne des composés de type polyphénols qui servent à inhiber l'expression du VCAM-1, l'expression du MCP-1 et/ou la prolifération des SMC chez un mammifère. Lesdits composés servent à réguler des marqueurs d'états inflammatoires, notamment l'inflammation vasculaire, et à assurer le traitement et la prévention de maladies inflammatoires et cardiovasculaires et d'états pathologiques associés.

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