Pharmaceutical compositions for the prevention and treatment...

A - Human Necessities – 61 – K

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A61K 31/473 (2006.01) A61K 31/465 (2006.01) A61K 45/06 (2006.01) A61P 25/14 (2006.01) A61P 25/16 (2006.01) A61P 25/18 (2006.01) A61P 25/22 (2006.01) A61P 25/28 (2006.01)

Patent

CA 2335012

A pharmaceutical composition incorporates a pharmaceutically effective amount of at least two components, one of those components being a nicotinic compound capable of interacting with nicotinic cholinergic receptors (e.g., a nicotinic agonist, such as E-metanicotine) and one of those components being an acetylcholinesterase inhibitor (e.g., tacrine). The pharmaceutical composition is useful for treating CNS disorders, such as Alzheimer's disease.

Une composition pharmaceutique contient une dose pharmaceutique efficace d'au moins deux constituants, un de ces constituants étant un composé nicotinique capable d'interagir avec les récepteurs cholinergiques nicotiniques (par exemple, un agoniste nicotinique tel que E-métanicotine) et un des ces constituants étant un inhibiteur d'acétycholinestérase (par exemple tacrine). La composition pharmaceutique est utile pour traiter des troubles du système nerveux central tels que la maladie d'Alzheimer.

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