Pharmaceutical compositions for the treatment of diseases...

Details Pharmaceutical compositions for the treatment of diseases... Pharmaceutical compositions for the treatment of diseases...

A - Human Necessities

61

K

A61K 31/553 (2006.01) A01N 1/02 (2006.01) A61K 49/00 (2006.01) A61P 25/28 (2006.01)

Patent

CA 2489965

The present invention refers to pharmaceutical preparations including as active compounds 3-aza-bicyclo[3.2.1]octane derivatives of general formula (I) and/or their dimers of general formula (II) and (III) acting as agonists of human neurotrophines. Therefore, such compounds of formula (I), (II) and (III) are useful for treatment of diseases in which the neurotrophine functions are involved in defect, particularly of Nerve Growth Factor (NGF), such as neurodegenerative diseases of central nervous system (CNS), acquired immundeficiency due to a reduced NGF biodisponibility, or morbous conditions in which the stimulus of neoangiogenesis process is convenient.

La présente invention se rapporte à des compositions pharmaceutiques contenant en tant que composés actifs des dérivés 3-aza-bicyclo[3.2.1]octane représentés par la formule générale (I) et/ou leurs dimères représentés par la formule générale (II) et (III) qui agissent en tant qu'agonistes des neurotrophines humaines. Ces composés représentés par la formule (I), (II) et (III) sont utiles pour le traitement des maladies dans lesquelles les neurotrophines fonctionnent de manière imparfaite, notamment le facteur de croissance neuronale (NGF), telles que les maladies neurodégénératives du système nerveux central (CNS), l'immuno-déficience acquise résultant d'une biodisponibilité réduite du NGF, ou les troubles nerveux dans lesquels la stimulation du processus de néoangiogenèse s'avère appropriée.

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