Pharmaceutical compositions for the treatment of transplant...

Details Pharmaceutical compositions for the treatment of transplant... Pharmaceutical compositions for the treatment of transplant...

A - Human Necessities

61

K

A61K 38/13 (2006.01) A61K 9/10 (2006.01) A61K 9/14 (2006.01) A61K 9/48 (2006.01) A61K 31/445 (2006.01) A61K 31/45 (2006.01) A61K 45/06 (2006.01)

Patent

CA 2261666

A synergistic combination of an IL-2 transcrip-tion inhibitor (e.g., cyclosporin A or FK506) and 40-O--(2-hydroxyethyl)-rapamycin is provided, which is use-ful in the treatment and prevention of transplant re-jection and also certain autoimmune and inflammatory diseases, together with novel pharmaceutical composi-tions comprising an IL-2 transcription inhibitor in com-bination with a rapamycin, e.g., 40-O-(2-hydroxyethyl)-rapamycin.

Divulgation d'une combinaison synergique d'un inhibiteur de transcription de l'IL-2 (par ex. la cyclosporine A ou FK506) et de la 40-O-(2-hydroxyéthyl)-rapamycine, utile pour le traitement et la prévention de rejets de greffon, ainsi que de certaines maladies auto-immunes et inflammatoires. Divulgation aussi de nouvelles compositions pharmaceutiques comprenant un inhibiteur de transcription de l'IL-2 en combinaison avec une rapamycine, par ex. la 40-O-(2- hydroxyéthyl)-rapamycine.

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