Pharmaceutical compositions for therapeutic use

Details Pharmaceutical compositions for therapeutic use Pharmaceutical compositions for therapeutic use

A - Human Necessities

61

K

A61K 39/39 (2006.01) A61K 39/21 (2006.01) A61K 39/29 (2006.01) A61K 39/295 (2006.01)

Patent

CA 2542680

The invention relates to therapeutic vaccines against pathogens which cause chronic diseases. More specifically, the invention relates to the use of the hepatitis B virus surface antigen (HBsAg) which is produced by recombinant means from Pichia pastoris, by way of a main component, in order to obtain pharmaceutical compositions for therapeutic purposes. The inventive compositions can comprise a combination of the hepatitis B antigen and other coadministered antigens. The aforementioned formulations can generate a strong lymphoproliferative response and cytotoxic T lymphocytes, as well as a significant specific antibody response. In this way, said formulations are very effective for the treatment of the above-mentioned diseases in humans.

L'invention concerne des vaccins thérapeutiques contre des pathogènes provoquant des maladies chroniques. L'invention concerne notamment l'utilisation de l'antigène de surface du virus de l'hépatite B (HBsAg), produit par recombinaison à partir de <i>Pichia pastoris</i>, comme constituant principal, pour l'obtention de compositions pharmaceutiques à des fins thérapeutiques. Celles-ci peuvent contenir une association du gène de l'hépatite b avec d'autres antigènes coadministrés. Ces formulations sont capables de générer une réponse lymphoproliférative puissante et des lymphocytes T cytotoxiques, en plus d'une réponse considérable d'anticorps spécifiques, ce qui les rend très efficaces dans le traitement desdites maladies chez des patients humains.

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