Pharmaceutical compositions for topical application

C - Chemistry – Metallurgy – 07 – D

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Details

C07D 311/72 (2006.01) A61K 31/27 (2006.01) A61K 31/335 (2006.01) A61K 31/405 (2006.01) C07C 323/41 (2006.01) A61K 7/40 (1990.01)

Patent

CA 2137105

A pharmaceutical and cosmetical preparation which rapidly penetrates through human skin, and which thus is able to bring about the rapid transdermal penetration of a wide variety of active ingredients. The compounds which enhance the rate of dermal penetration are also anti-oxidative agents and thus protect active substances susceptible to oxidative degradation. Preferred agents enhancing penetration and which protect against oxidation are higher esters and higher amides of thioglycolic acid and of mercaptopropionic acid. The preparations can be in the form of mixtures or there may be prepared chemical compounds which are a combination of the active substance and the said thioacids.

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