A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/7042 (2006.01) A61K 31/70 (2006.01) A61K 31/7004 (2006.01) A61P 1/16 (2006.01)
Patent
CA 2711673
Disclosed is a pharmaceutical composition which is useful as a therapeutic agent for fatty liver diseases. The pharmaceutical composition comprises (1S)-1,5-anhydro-1-[5-(azulen-2-ylmethyl)- 2-hydroxyphenyl]-D-glucitol or a pharmaceutically acceptable salt thereof, (1S)-1,5-anhydro-1-[3-(1-benzothiophen-2-ylmethyl)-4- fluorophenyl]-D-glucitol or a pharmaceutically acceptable salt thereof, or (1S)-1,5-anhydro-1-[4-(chloro-3-(4- ethoxybenzyl)phenyl)-D-glucitol or a pharmaceutically acceptable salt thereof. The pharmaceutical composition can be used for the treatment of fatty liver diseases, specifically non-alcoholic fatty liver diseases, more specifically non-alcoholic simple steatosis and/or non- alcoholic steatohepatitis.
L'invention concerne une composition pharmaceutique qui est utile comme agent thérapeutique pour des stéatoses hépatiques. La composition pharmaceutique comprend du (1S)-1,5-anhydro-1-[5-(azulén-2-ylméthyl)-2-hydroxyphényl]-D-glucitol ou un sel pharmaceutiquement acceptable de celui-ci, du (1S)-1,5-anhydro-1-[3-(1-benzothiophén-2-ylméthyl)-4-fluorophényl]-D-glucitol ou un sel pharmaceutiquement acceptable de celui-ci, ou du (1S)-1,5-anhydro-1-[4-(chloro-3-(4- éthoxybenzyl)phényl)-D-glucitol ou un sel pharmaceutiquement acceptable de celui-ci. La composition pharmaceutique peut être utilisée pour le traitement de stéatoses hépatiques, particulièrement des stéatoses hépatiques non alcooliques, plus particulièrement des stéatoses simples non alcooliques et/ou d'une stéatohépatite non alcoolique.
Kurosaki Eiji
Maeda Noriaki
Takasu Toshiyuki
Yamazaki Shunji
Astellas Pharma Inc.
Dennison Associates
Kotobuki Pharmaceutical Co. Ltd.
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