Pharmaceutical compositions having good dissolution properties

Details Pharmaceutical compositions having good dissolution properties Pharmaceutical compositions having good dissolution properties

A - Human Necessities

61

K

A61K 31/42 (2006.01) A61K 9/20 (2006.01) A61K 9/32 (2006.01) A61K 9/48 (2006.01) A61K 47/02 (2006.01)

Patent

CA 2129099

Abstract PHARMACEUTICAL COMPOSITIONS HAVING GOOD DISSOLUTION ION PROPERTIES An ifetroban composition is provided which has good dissolution properties even on aging, when dispersed in water has a pH of at least 7 and includes a salt of ifetroban, one or more basifying agents, such as magnesium oxide or calcium carbonate, and where in tablet form includes one or more fillers such as mannitol and/or microcrystalline cellulose, one or more disintegrating agents such as crospovidone, one or more lubricants such as magnesium stearate, optionally one or more glidants such as colloidal silicon dioxide, one or more binders such as pregelatinized starch (dry binder) or polyvinyl-pyrrolidone (wet binder) and optionally a film coating containing a film former such as hydroxypropyl cellulose and a plasticizer such as 1,2,3-propanetriol triacetate.

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