Pharmaceutical compositions having reduced bitter taste

Details Pharmaceutical compositions having reduced bitter taste Pharmaceutical compositions having reduced bitter taste

A - Human Necessities

61

K

A61K 9/00 (2006.01) A61K 9/14 (2006.01)

Patent

CA 2521253

Masking the taste of bitter pharmaceuticals in dispersible compositions is difficult. A novel formulation for dispersible compositions has been found where the bitterness of active ingredients is reduced and the amount of lipid in the formulation is minimised thereby reducing the retardation affect lipids have on release of the active ingredient from the composition. The invention is particularly relevant to basic bitter tasting pharmaceuticals such as macrolide antibiotics, especially erythromycin, roxithromycin, azithromycin, and clarithromycin.

Il est difficile de masquer le goût amer de produits pharmaceutiques dans des compositions dispersibles. La présente invention a trait à une nouvelle formulation pour compositions dispersibles dans laquelle le goût amer des principes actifs est réduite et la quantité de lipide dans la formulation est minimisée réduisant ainsi l'effet de retard que présentent les lipides sur la libération du principe actif de la composition. L'invention est particulièrement applicable aux produits pharmaceutiques amers, tels que des antibiotiques de la famille des macrolides, notamment l'érythromycine, la roxithromycine, l'azithromycine, et la clarithromycine.

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