A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
167/165, 167/209
A61K 9/16 (2006.01) A61K 9/26 (2006.01) A61K 9/50 (2006.01) A61K 31/40 (2006.01) A61K 31/55 (2006.01) A61K 47/38 (2006.01)
Patent
CA 1323833
Abstract NEW PHARMACEUTICAL COMPOSITIONS IN THE FORM OF BEADLETS AND METHOD A pharmaceutical composition is provided which is in the form of a plurality of beadlets, adapted to be filled into pharmaceutical hard shell capsules, or compressed into tablets, which beadlets are formed of a pharmaceutical such as an ACE inhibitor, for example, captopril, a beta-blocker such as nadolol, propranolol or atenolol, a calcium channel blocker such as diltiazem or nifedipine or other pharmaceuticals including combinations thereof, binder such as microcrystalline cellulose, and at least 5% by weight of an acid processing aid, such as citric acid, which imparts plasticity to the wet mass needed for efficient extrusion and spheronization. A method for forming beadlets is also provided which includes the steps of extruding a composition as described above, and subjecting the resulting extrudate to a spheronization step wherein an acid processing aid such as citric acid is employed to improve processing and form improved beadlets.
559971
Bachman William R.
Jain Nemichand B.
Joshi Yatindra M.
E.r. Squibb & Sons Inc.
Osler Hoskin & Harcourt Llp
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