A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/4985 (2006.01) A61K 9/20 (2006.01) A61K 9/28 (2006.01) A61K 31/495 (2006.01) A61K 47/02 (2006.01) A61K 47/10 (2006.01) A61K 47/36 (2006.01) A61K 47/38 (2006.01)
Patent
CA 2467490
The present invention is directed to controlled-release (CR) oral pharmaceutical dosage forms of 5,8,14-triazatetracyclo[10.3.1.02,11.04,9]- hexadeca-2(11 ),3,5,7,9-pentaene, 1, and pharmaceutically acceptable salts thereof, and methods of using them to reduce nicotine addiction or aiding in the cessation or lessening of tobacco use while reducing nausea as an adverse effect. The present invention also relates to an immediate-release (IR) low dosage composition having a stable formulation with uniform drug distribution and potency.
L'invention se rapporte à la libération contrôlée de formes de dosage pharmaceutique oral de 5,8,14-triazatetracyclo[10.3.1.0?2,11¿.0?4,9¿]-hexadeca-2(11 ),3,5,7,9-pentaene, 1, et de sels pharmaceutiquement acceptables de ce dernier, ainsi qu'à des procédés d'utilisation afin de réduire la dépendance à la nicotine ou d'interrompre ou diminuer la consommation de tabac tout en réduisant les nausées comme effets indésirables. L'invention concerne aussi la libération immédiate d'une composition à faible dosage présentant une formulation stable ainsi qu'une administration et une activité médicamenteuse régulières.
Am Ende Mary Tanya
Moses Sara Kristen
Quan Ernest Shing
Roy Michael Christopher
Smith Scott Wendell
Pfizer Products Inc.
Smart & Biggar
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