Pharmaceutical compositions of atorvastatin

Details Pharmaceutical compositions of atorvastatin Pharmaceutical compositions of atorvastatin

A - Human Necessities

61

K

A61K 31/40 (2006.01) A61J 3/02 (2006.01) A61K 9/16 (2006.01)

Patent

CA 2465565

A wet granulated pharmaceutical composition comprising atorvastatin or a pharmaceutically acceptable salt thereof with less than about 5 weight% of an alkaline earth metal salt additive with a disintegrant which provides the atorvastatin with not more than about 3% atorvastatin lactone based on the ratio of lactone peak area compared to the total drug-related peak integrated areas, as well as said wet granulated pharmaceutical composition comprising atorvastatin or a pharmaceutically acceptable salt thereof in combination with at least one other active drug, methods for preparing said compositions, kits for containing such compositions, and a method of treating hypercholesterolemia and/or hyperlipidemia, osteoporosis, benign prostatic hyperplasia (BPH), and Alzheimer's disease using a therapeutically effective amount of the pharmaceutical compositions.

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