A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 47/10 (2006.01) A61K 31/5513 (2006.01) A61K 47/14 (2006.01) A61K 47/22 (2006.01) A61P 25/08 (2006.01)
Patent
CA 2662197
The present invention includes benzodiazepine compositions formulated for intranasal administration, comprising a binary solvent system comprising a first solvent in which the benzodiazepine is soluble, the first solvent capable of penetrating nasal mucosal tissue, and a second solvent in which the benzodiazepine in less soluble. The compositions of the present invention may be used to treat a variety of disorders including, but not limited to, panic attacks, muscle spasms, anxiety, and seizures. In one aspect, the present invention relates to a fast-acting, clonazepam composition for transnasal administration that can be used for the treatment of seizure clusters.
La présente invention concerne des compositions de benzodiazépine formulées pour administration intranasale, comprenant un système de solvant binaire comprenant un premier solvant dans lequel la benzodiazépine est soluble, le premier solvant étant capable de pénétrer le tissu muqueux nasal, et un second solvant dans lequel la benzodiazépine est moins soluble. Les compositions de la présente invention peuvent être utilisées pour traiter différents troubles comprenant, sans y être limités, des attaques de panique, des spasmes musculaires, l'anxiété et des crises d'épilepsie. Dans un aspect, la présente invention concerne une composition de clonazépam à action rapide pour administration transnasale qui peut être utilisée pour le traitement de séries de crises d'épilepsies.
Allphin Clark
Des Jardin Michael
Jamieson Gene
Olafsdottir Sigridur
Gowling Lafleur Henderson Llp
Jazz Pharmaceuticals Inc.
Olafsdottir Sigridur
LandOfFree
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