A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/565 (2006.01) A61K 31/566 (2006.01) A61K 31/568 (2006.01) A61K 31/57 (2006.01) A61K 47/02 (2006.01) A61P 15/02 (2006.01) A61P 19/10 (2006.01)
Patent
CA 2402559
A composition of matter is provided having a mixture of active estrogenic compounds. The mixture is present in chemically pure form. The mixture includes salts of conjugated estrone, conjugated equilin, conjugated .DELTA.8,9-dehydroestrone, conjugated 17.alpha.-estradiol, conjugated 17.alpha.-dihydroequilin, conjugated 17.alpha.-dihydroequilin, conjugated 17.beta.-estradiol, conjugated equilenin, conjugated 17.alpha.- dihydroequilenin, and conjugated 17.beta.-dihydroequilenin. The mixture also contains the same essential estrogenic compounds present in naturally derived equine conjugated estrogens. Drug products including the composition of matter are also provided, as are methods of using these drug products to treat mammals in need of treatment. Methods of analyzing mixtures containing conjugated estrogens are also provided.
L'invention concerne une composition de matière présentant un mélange de composés oestrogéniques actifs. Le mélange est présent en une forme chimiquement pure. Le mélange contient des sels d'estrone conjuguée, équiline conjuguée, de .DELTA.?8,9¿-déhydroestrone conjuguée, 17.alpha.-estradiol conjugué, 17.alpha.-dihydroéquiline conjuguée, 17.beta.-dihydroéquiline conjuguée, 17.beta.-estradiol conjugué, équiline conjuguée, 17.alpha.-dihydroéquiline conjuguée, et 17.beta.-dihydroéquiline conjuguée. Le mélange contient également les mêmes composés oestrogéniques essentiels présents dans des oestrogènes équins conjugués dérivés naturellement. L'invention concerne également des produits médicamenteux contenant la composition de matière, ainsi que des méthodes d'utilisation de ces produits médicamenteux pour traiter des mammifères nécessitant un traitement. L'invention concerne aussi des méthodes d'analyse de mélanges contenant des oestrogènes conjugués.
Hill Edward N.
Leonard Thomas W.
Sancilio Frederick D.
Schlipp Katherin M.
Shirazi Dean G.
Duramed Pharmaceuticals Inc.
Endeavor Pharmaceuticals Incorporated
Robic
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