A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/275 (2006.01) A61K 9/14 (2006.01) A61K 9/16 (2006.01) A61K 9/26 (2006.01) A61K 31/195 (2006.01) A61K 31/198 (2006.01) A61K 47/26 (2006.01)
Patent
CA 2714112
The present invention relates to single oral dose pharmaceutical compositions comprising a combination of entacapone, levodopa and carbidopa, or salts thereof along with one or more sugar alcohols, wherein the entacapone is co-micronized with one or more sugar alcohols. The composition of the invention exhibits bioequivalence to commercially available entacapone, levodopa and carbidopa combination formulation marketed under the trade name Stalevo200®. The invention also relates to processes for making such compositions.
La présente invention se rapporte à des compositions pharmaceutiques orales unidoses comprenant une combinaison d'entacapone, de lévodopa et de carbidopa, ou des sels de ceux-ci avec un ou plusieurs alcools glucidiques, l'entacapone étant co-micronisé avec un ou plusieurs alcools glucidiques. La composition de l'invention présente une bioéquivalence avec la formulation de combinaison d'entacapone, de lévodopa et de carbidopa disponible dans le commerce sous le nom Stalevo200®. L'invention se rapporte également à des processus de fabrication de telles compositions.
Jain Girish Kumar
Kapoor Ritesh
Mashalkar Manoj
Talwar Munish
Smart & Biggar
Wockhardt Research Centre
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