Pharmaceutical compositions of hdac inhibitors and...

Details Pharmaceutical compositions of hdac inhibitors and... Pharmaceutical compositions of hdac inhibitors and...

A - Human Necessities

61

K

A61K 31/167 (2006.01) A61P 35/00 (2006.01) A61K 33/26 (2006.01) A61K 33/30 (2006.01)

Patent

CA 2663569

The present invention provides pharmaceutical compositions of an HDAC inhibitor and a chelatable metal compound. In one embodiment, the invention provides a method of treating cancer and alleviating the side effects of the HDAC inhibitor by administering the pharmaceutical composition. In another embodiment, the present invention also provides pharmaceutical compositions of metal HDAC inhibitor chelate complexes. In another embodiment, the invention provides methods of treating cancer by administering the pharmaceutical compositions. The invention provides crystalline compositions of metal HDAC inhibitor chelate complexes and methods of producing same.

La présente invention concerne des compositions pharmaceutiques d'un inhibiteur HDAC et d'un composé métallique chélatable. Dans un mode de réalisation, l'invention concerne une méthode de traitement du cancer et d'atténuation des effets secondaires de l'inhibiteur HDAC, par administration de la composition pharmaceutique. Dans un autre mode de réalisation, l'invention concerne des compositions pharmaceutiques de complexes métalliques chélatés de l'inhibiteur HDAC. Dans un autre mode de réalisation, l'invention concerne des méthodes de traitement du cancer par administration de compositions pharmaceutiques. L'invention concerne en outre des compositions cristallines de complexes métalliques chélatés de l'inhibiteur HDAC et des méthodes de production desdites compositions.

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