Pharmaceutical compositions of hiv protease inhibitors with...

Details Pharmaceutical compositions of hiv protease inhibitors with... Pharmaceutical compositions of hiv protease inhibitors with...

A - Human Necessities

61

K

A61K 31/425 (2006.01) A61K 9/48 (2006.01) A61K 31/341 (2006.01) A61K 31/426 (2006.01) A61K 31/4433 (2006.01) A61K 31/47 (2006.01) A61K 31/4704 (2006.01) A61K 31/4725 (2006.01) A61K 31/496 (2006.01) A61K 31/513 (2006.01) A61K 31/535 (2006.01) A61K 31/5375 (2006.01) A61K 31/55 (2006.01) A61K 31/551 (2006.01) A61K 38/05 (2006.01) A61K 38/55 (2006.01) A61K 47/10 (2006.01) A61K 47/12 (2006.01) A61K 47/26 (2006.01) A61K 47/44 (2006.01)

Patent

CA 2271196

A liquid pharmaceutical composition providing improved oral bioavailability is disclosed for compounds which are inhibitors of HIV protease. In particular, the composition comprises a solution in a pharmaceutically acceptable organic solvent of (a) the HIV protease inhibitor and optionally, (b) a surfactant. The composition can optionally be encapsulated in either hard gelating capsules or soft elastic capsules (SEC).

L'invention concerne une composition pharmaceutique liquide assurant une meilleure biodisponibilité orale et destinée aux composés constituant des inhibiteurs de la protéase du VIH. La composition comprend notamment une solution dans un solvant organique pharmaceutiquement acceptable (a) de l'inhibiteur de la protéase du VIH et, en option, (b) d'un tensioactif. La composition peut être encapsulée dans des capsules gélatineuses dures ou dans des capsules élastiques molles (capsules SEC).

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