A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
167/103.2
A61K 37/02 (1990.01)
Patent
CA 1283356
Abstract of the Disclosure A sterile, stable lyophilized formulation of selectively oxidized microbially produced recombinant IL-2 in which the recombinant IL-2 is admixed with a water soluble carrier such as mannitol that provides bulk, and a sufficient amount of sodium dodecyl sulfate to ensure the solubility of the recombinant IL-2 in water. The formulation is suitable for reconstitution in aqueous injections for parenteral administration and it is stable and well tolerated in human patients. Fig. 1 illustrates a preferred method of purifying recombinant IL-2 suitable for use in preparing the formulations of the present invention.
490072
Fernandes Peter
Taforo Terrance
Borden Ladner Gervais Llp
Novartis Vaccines And Diagnostics Inc.
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