Pharmaceutical compositions of rhein or diacerein

A - Human Necessities – 61 – K

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Details

A61K 9/58 (2006.01) A61K 9/16 (2006.01) A61K 9/48 (2006.01) A61K 31/192 (2006.01) A61P 19/02 (2006.01) A61P 29/00 (2006.01)

Patent

CA 2709236

The invention relates to pharmaceutical compositions of rhein or diacerein, or salts or esters or prodrugs thereof which are bioequivalent to a 50 mg diacerein formulation marketed under the trade name Art 50?. The compositions exhibit no variability in fed and fasted state conditions. The compositions also result in significant reduction in side effects such as, soft stools as compared to Art 50?. The invention also relates to the methods for preparing such compositions.

L'invention porte sur des compositions pharmaceutiques de rhéineou de diacéréine, ou sur leurs sels ou esters ou promédicaments qui sont bio-équivalents à une formulation de diacéréinede 50 mg commercialisée sous l'appellation commerciale Art 50®. Les compositions ne présentent aucune variabilité dans les conditions d'état à jeun et non à jeun. Les compositions conduisent également à une réduction significative des effets secondaires, tels que des selles molles, par rapport à Art 50®. L'invention porte également sur les procédés pour préparer de telles compositions.

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