A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 9/06 (2006.01) A61K 31/00 (2006.01) A61K 47/10 (2006.01) A61K 47/38 (2006.01)
Patent
CA 2654383
The present invention comprises compositions for pharmaceutical drug delivery of an indolone (e.g., ropinirole), or a pharmaceutically acceptable salt thereof. The composition may, for example, be a gel suitable for transdermal application. The compositions of the present invention typically comprise a hydroalcoholic vehicle, one or more antioxidant, and one or more buffering agent, wherein the pH of the gel is usually between about pH 7 and about pH 9. The compositions may include further components, for example, the hydroalcoholic vehicle may further comprise additional solvent(s), antioxidant(s), cosolvent(s), penetration enhancer{s), buffering agent(s), and/or gelling agent(s). The compositions may be used for the treatment of a variety of neurological disorders.
La présente invention comprend des compositions destinées à la libération médicamenteuse d'une indolone (par exemple le ropinirole), ou de l'un de ses sels de qualité pharmaceutique. La composition peut, par exemple, être un gel adapté à une application transdermique. Les compositions selon la présente invention comprennent typiquement un véhicule hydroalcoolique, un ou plusieurs antioxydants, et un ou plusieurs agents tampon, le pH du gel étant généralement compris entre environ 7 et environ 9. Les compositions peuvent inclure d'autres composants, par exemple, le véhicule hydroalcoolique peut en outre comprendre un ou plusieurs solvants, antioxydants, cosolvants, agents amplificateurs de pénétration, agents tampon et/ou gélifiants supplémentaires. Les compositions peuvent être employées dans le traitement de divers troubles neurologiques.
Carrara Dario Norberto
Grenier Arnaud
Jamieson Gene
Jazz Pharmaceuticals
Smart & Biggar
LandOfFree
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