Pharmaceutical compositions with attenuated release of...

Details Pharmaceutical compositions with attenuated release of... Pharmaceutical compositions with attenuated release of...

A - Human Necessities

61

K

A61K 31/155 (2006.01) A61K 31/485 (2006.01) A61P 29/00 (2006.01) A61P 43/00 (2006.01)

Patent

CA 2739936

Pharmaceutical compositions and their methods of use are provided, where the pharmaceutical compositions comprise a phenolic opioid prodrug that provides enzymatically-controlled release of a phenolic opioid, and an enzyme inhibitor that interacts with the enzyme(s) that mediates the enzymatically-controlled release of the phenolic opioid from the prodrug so as to attenuate enzymatic cleavage of the prodrug.

L'invention porte sur des compositions pharmaceutiques et sur leurs procédés d'utilisation. Les compositions pharmaceutiques comprennent un promédicament opioïde phénolique qui permet une libération contrôlée enzymatiquement d'un opioïde phénolique, et un inhibiteur d'enzyme qui interagit avec la ou les enzymes qui servent de médiateur à la libération contrôlée enzymatiquement de l'opioïde phénolique à partir du promédicament de façon à atténuer un clivage enzymatique du promédicament.

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