Pharmaceutical compositions with enhanced stability

A - Human Necessities – 61 – K

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A61K 38/00 (2006.01) A01N 59/16 (2006.01) A61K 33/32 (2006.01)

Patent

CA 2637569

The present invention provides for a stabilized biodegradable polymeric composition useful as a controlled release delivery system for peptide agents. The compositions of the present invention comprise a) a beneficial salt of a peptide agent formed with a strong acid that minimizes or prevents the interaction/reaction between the peptide agent and the polymer in an organic solution; b) a biodegradable polymer; c) a pharmaceutically acceptable organic solvent; and d) optionally one or more excipients . The present invention also relates to a method of manufacturing and a method of use thereof .

La présente invention concerne une composition polymérique stabilisée biodégradable utile en tant que système d~administration à libération contrôlée d~agents peptides. Les compositions de la présente invention comprennent a) un sel bénéfique d~agent peptide formé avec un acide fort qui minimise ou empêche l~interaction/réaction entre l~agent peptide et le polymère dans une solution organique, b) un polymère biodégradable, c) un solvant organique pharmaceutiquement acceptable et d) en option, un ou plusieurs excipients. La présente invention concerne aussi un procédé de fabrication et d~utilisation des compositions citées.

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