A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/635 (2006.01) A61K 31/415 (2006.01) A61K 31/455 (2006.01) C07B 63/00 (2006.01) G01N 15/14 (2006.01) G01N 21/27 (2006.01) G01N 25/08 (2006.01) G01N 25/12 (2006.01) G01N 33/15 (2006.01)
Patent
CA 2511881
The invention relates to methods of screening mixtures containing a pharmaceutical compound and an excipient to identify properties of the pharmaceutical compound/excipient combination that retard solid-state nucleation. The invention further relates to increasing the solubility, dissolution and bioavailability of a drug with low solubility in gastric fluids conditions by combining the drug with a precipitation retardant and an optional enhancer.
L'invention concerne des méthodes permettant de cribler des mélanges contenant un composant pharmaceutique et un excipient afin d'identifier les propriétés de la combinaison composant pharmaceutique/excipient retardatrice de la nucléation à l'état solide. L'invention concerne également l'augmentation de la solubilité, de la dissolution et de la biodisponibilité d'un médicament à faible solubilité dans des conditions de fluides gastriques par combinaison du médicament avec un agent retardateur de précipitation et d'un éventuel amplificateur.
Almarsson Orn
Chen Hongming
Guzman Hector
Oliveira Mark
Peterson Matthew
Osler Hoskin & Harcourt Llp
Transform Pharmaceuticals Inc.
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