A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 9/20 (2006.01) A61K 9/14 (2006.01) A61K 9/28 (2006.01) A61K 9/48 (2006.01) A61K 9/64 (2006.01) A61K 31/18 (2006.01) A61K 31/365 (2006.01) A61K 31/415 (2006.01) A61K 31/635 (2006.01)
Patent
CA 2489984
The invention relates to methods of screening mixtures containing a pharmaceutical compound an excipient to identify properties of the pharmaceutical compound/excipient combination that retard solid-state nucleation. The invention further relates to increasing the solubility, dissolution and bioavailability of a drug with low solubility in gastric fluids conditions by combining the drug with a recrystallization/precipitation retardant and an optional enhancer.
Cette invention a trait à des méthodes de criblage de mélanges contenant un composé à usage pharmaceutique et un excipient, afin d'identifier les propriétés de cette combinaison retardant la nucléation à l'état solide. L'invention a également trait à l'amélioration de la solubilité, de la dissolution et de la biodisponibilité d'un médicament dans des liquides gastriques et ce, par association du médicament avec un agent retardateur de la recristallisation/précipitation et, éventuellement, avec un agent renforceur.
Almarsson Orn
Chen Hongming
Guzman Hector
Oliveira Mark
Peterson Matthew
Osler Hoskin & Harcourt Llp
Transform Pharmaceuticals Inc.
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